The FA Cup quarterfinal matchups are set after the draw on Wednesday, with Premier League leaders Manchester City matched up against Newcastle United at the Etihad Stadium.

The holders will face a Newcastle side exceeding expectations and sitting fifth in the Premier League table. Still, Pep Guardiola’s men will be heavily favored to advance at home as they pursue a seventh FA Cup title.

Intriguing North West Derby Possible

One of the other quarterfinal ties could be a blockbuster if both Manchester United and Liverpool take care of business in their fifth round replays. United must get by Championship club Nottingham Forest, while Liverpool face a tricky test against Southampton.

Should both come through those matches unscathed, they would meet at Old Trafford in a titanic North West derby between two of English football’s most decorated clubs. Their rivalry needs no introduction, and an FA Cup meeting would add another chapter.

Underdogs Look to Pull Off Upsets

While the Premier League clubs are heavy favorites in their quarterfinal matchups, don’t count out the underdogs. Coventry City, currently riding high in eighth place in the Championship, will travel to Brighton or Wolves dreaming of an upset.

The Sky Blues are the lowest-ranked team left in the competition and would relish being the proverbial David taking down one of the Premier League Goliaths. With a raucous away support behind them, they have a fighter’s chance.

With quarterfinal places on the line, every club still involved will be giving everything to keep their Wembley dreams alive. Anything can happen in cup competitions, and with matchup between giants and underdogs, the stage is set for more FA Cup magic.